Compound Detail
CHEMBL1928884
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1928884 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZOURIJYMFADDZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
377.3
MW (Da)
4.03
ALogP
4
HBA
1
HBD
56.1
PSA (Ų)
0.69
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mineralocorticoid receptor CHEMBL1994 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 24.0 | mL.min-1.g-1 | Rattus norvegicus |
| F | 28.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | IC50 | = | 260.0 | nM | 6.58 | Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cell... | 22074142 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22074142 | 10.1021/jm2011645 | Mineralocorticoid receptor | 1 |
| 22074142 | 10.1021/jm2011645 | Liver microsomes | 1 |
| 22074142 | 10.1021/jm2011645 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine