Compound Detail
CHEMBL1939880
BI 4395 Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1939880 |
| Name | BI 4395 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOIUQQUDMFDDDC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
3.20
ALogP
4
HBA
3
HBD
100.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(1B) dopamine receptor CHEMBL1850 | Ki | 5.0 | 5.0 | 10000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(1B) dopamine receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of D5 | - |
| D(1B) dopamine receptor | Ki | = | 10000.0 | nM | 5.0 | GPCRScan assay: inhibition of D5 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4689842 | Fibroblast | 261 |
| - | 10.6019/CHEMBL4689842 | U2OS | 260 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 259 |
| - | 10.6019/CHEMBL4507281 | Tyrosine-protein kinase ABL1 | 15 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4507281 | Epidermal growth factor receptor | 12 |
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4507281 | Receptor-type tyrosine-protein kinase FLT3 | 11 |
| - | 10.6019/CHEMBL4507281 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 10 |
| - | 10.6019/CHEMBL4507281 | Mast/stem cell growth factor receptor Kit | 9 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 6 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.6019/CHEMBL5303304 | U2OS | 5 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL4507281 | Proto-oncogene tyrosine-protein kinase receptor Ret | 4 |
| - | 10.6019/CHEMBL4507281 | D(1B) dopamine receptor | 3 |
| - | 10.6019/CHEMBL4507281 | Hepatocyte growth factor receptor | 3 |
| - | 10.6019/CHEMBL4507281 | ALK tyrosine kinase receptor | 3 |
| - | 10.6019/CHEMBL4507281 | Ribosomal protein S6 kinase alpha-4 | 2 |
| - | 10.6019/CHEMBL4507281 | Ribosomal protein S6 kinase alpha-5 | 2 |
Data from ChEMBL 36 via Core Engine