Compound Detail
CHEMBL1945767
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1945767 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIIWJCLTQAZNFZ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
421.4
MW (Da)
6.79
ALogP
2
HBA
1
HBD
38.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Tissue-type plasminogen activator CHEMBL1873 | IC50 | 5.28 | 5.28 | 5300.0 | 1 |
| Plasminogen CHEMBL1801 | IC50 | 5.19 | 5.19 | 6500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | IC50 | = | 2100.0 | nM | 5.68 | Non-competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substr... | 22285569 |
| Tissue-type plasminogen activator | IC50 | = | 5300.0 | nM | 5.28 | Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preinc... | 22285569 |
| Plasminogen | IC50 | = | 6500.0 | nM | 5.19 | Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate p... | 22285569 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22285569 | 10.1016/j.bmc.2011.12.040 | Plasminogen | 1 |
| 22285569 | 10.1016/j.bmc.2011.12.040 | Tissue-type plasminogen activator | 1 |
| 22285569 | 10.1016/j.bmc.2011.12.040 | Prothrombin | 1 |
| 22285569 | 10.1016/j.bmc.2011.12.040 | Urokinase-type plasminogen activator | 1 |
Data from ChEMBL 36 via Core Engine