Compound Detail
CHEMBL1951281
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Basic Information
| ChEMBL ID | CHEMBL1951281 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KZMZIUKHHNRIMU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
366.5
MW (Da)
1.60
ALogP
7
HBA
2
HBD
92.2
PSA (Ų)
0.69
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
| Glycylpeptide N-tetradecanoyltransferase CHEMBL3988596 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of Trypanosoma brucei N-myristoyltransferase using [3H]myristoyl-CoA ... | 22148754 |
| Glycylpeptide N-tetradecanoyltransferase | IC50 | = | 2400.0 | nM | 5.62 | Enzyme Inhibition Assay: Measurements were performed using a modification of the... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22148754 | 10.1021/jm201091t | Unchecked | 1 |
| 22148754 | 10.1021/jm201091t | Glycylpeptide N-tetradecanoyltransferase 1 | 1 |
Data from ChEMBL 36 via Core Engine