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Compound Detail

CHEMBL197604

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C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O.[Br-].[Br-]

Basic Information

ChEMBL ID CHEMBL197604
Phase Preclinical
Structure Type MOL
InChI Key PRKPEGFLSAHXKC-UHFFFAOYSA-L
Parent Compound CHEMBL1181935
Active Moiety CHEMBL1181935
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

496.7
MW (Da)
3.01
ALogP
3
HBA
0
HBD
57.7
PSA (Ų)
0.18
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H44Br2N4O3
MW 656.50
Aromatic Rings 1
Heavy Atoms 36
NP-Likeness -0.34

Activity Summary

EC50 1 meas. best 7.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL4781
EC50 7.22 7.22 60.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M3 4
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M2 4
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M1 2

Data from ChEMBL 36 via Core Engine