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Compound Detail

CHEMBL20173

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CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H](CC(=O)N(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)(C)C)C(=O)O

Basic Information

ChEMBL ID CHEMBL20173
Phase Preclinical
Structure Type MOL
InChI Key QCUFMVVWFUYWRO-LMXVXWCUSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

763.9
MW (Da)
-0.53
ALogP
10
HBA
9
HBD
286.7
PSA (Ų)
0.08
QED
2
Ro5 Violations
20
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H57N7O11
MW 763.89
Aromatic Rings 1
Heavy Atoms 54
NP-Likeness 0.11

Activity Summary

IC50 2 meas. best 6.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.7 5.68 200.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80215-2 Unchecked 3

Data from ChEMBL 36 via Core Engine