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Compound Detail

CHEMBL2024624

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COc1cc(/C=C/C(=O)O[C@H]2CC[C@]3(C)[C@H]4C(=O)C=C5[C@@H]6C[C@@](C)(C(=O)O)CC[C@]6(C)CC[C@@]5(C)[C@]4(C)CC[C@H]3C2(C)C)cc(OC)c1OC

Basic Information

ChEMBL ID CHEMBL2024624
Phase Preclinical
Structure Type MOL
InChI Key BONZPWUSYVCKJD-FSFONNLQSA-N
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

690.9
MW (Da)
8.70
ALogP
7
HBA
1
HBD
108.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C42H58O8
MW 690.92
Aromatic Rings 1
Heavy Atoms 50
NP-Likeness 2.43

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
22520261 10.1016/j.bmcl.2012.03.081 Hepatitis B virus 3
22520261 10.1016/j.bmcl.2012.03.081 Unchecked 3
22520261 10.1016/j.bmcl.2012.03.081 ADMET 1

Data from ChEMBL 36 via Core Engine