Compound Detail
CHEMBL202518
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Basic Information
| ChEMBL ID | CHEMBL202518 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AQQRGNNYEPRIIF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
256.4
MW (Da)
3.01
ALogP
3
HBA
0
HBD
44.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Ki 1 meas. best 5.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.23 | 5.23 | 5900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of [3H] dopamine uptake into human DAT expressed in HEK293 cells | 16480278 |
| Sodium-dependent dopamine transporter | Ki | = | 5900.0 | nM | 5.23 | Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cells | 16480278 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16480278 | 10.1021/jm050797a | Sodium-dependent dopamine transporter | 2 |
| 16480278 | 10.1021/jm050797a | Sodium-dependent serotonin transporter | 1 |
| 16480278 | 10.1021/jm050797a | Sodium-dependent noradrenaline transporter | 1 |
Data from ChEMBL 36 via Core Engine