Compound Detail
CHEMBL2028661
AZILSARTAN MEDOXOMIL 💊 Approved Drug
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💊 Approved Drug
CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1
Basic Information
| ChEMBL ID | CHEMBL2028661 |
| Name | AZILSARTAN MEDOXOMIL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QJFSABGVXDWMIW-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL57242 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names
3
Indications
Molecular Properties
568.5
MW (Da)
4.71
ALogP
11
HBA
1
HBD
155.6
PSA (Ų)
0.24
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2011 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Cardiovascular Diseases Essential Hypertension Hypertension
ATC Classification
C09CA09
azilsartan medoxomil
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Activity Summary
IC50 1 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-2 angiotensin II receptor CHEMBL4607 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-2 angiotensin II receptor | IC50 | = | 2.6 | nM | 8.59 | Inhibition of Angiotensin-2 receptor (unknown origin) | 38889609 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 38889609 | 10.1016/j.ejmech.2024.116593 | Type-2 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine