Compound Detail
CHEMBL2037371
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Basic Information
| ChEMBL ID | CHEMBL2037371 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PLQCDKKQKRJJDK-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
277.3
MW (Da)
2.95
ALogP
2
HBA
0
HBD
37.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Regulator of G-protein signaling 4 CHEMBL1795091 | IC50 | 4.03 | 4.03 | 93000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Regulator of G-protein signaling 4 | IC50 | = | 93300.0 | nM | 4.03 | Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein in... | 22368763 |
| Regulator of G-protein signaling 4 | IC50 | = | 93000.0 | nM | 4.03 | Inhibitory Assay: FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22368763 | 10.1021/ml200263y | Regulator of G-protein signaling 4 | 1 |
| 22368763 | 10.1021/ml200263y | Regulator of G-protein signaling 8 | 1 |
| 22368763 | 10.1021/ml200263y | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine