Compound Detail
CHEMBL204545
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Basic Information
| ChEMBL ID | CHEMBL204545 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCUJGNURAQMQRC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
418.4
MW (Da)
5.51
ALogP
6
HBA
1
HBD
78.1
PSA (Ų)
0.38
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4818 | EC50 | 5.2 | 5.2 | 6300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | EC50 | = | 6300.0 | nM | 5.2 | Effect on blockade of mouse Kv1.3 channel expressed in L929 cells | 16480279 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16480279 | 10.1021/jm050839v | Potassium voltage-gated channel subfamily A member 3 | 1 |
Data from ChEMBL 36 via Core Engine