Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2049164

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O

Basic Information

ChEMBL ID CHEMBL2049164
Phase Preclinical
Structure Type BOTH
InChI Key QVVDVENEPNODSI-BTNSXGMBSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

955.1
MW (Da)
-7.60
ALogP
13
HBA
25
HBD
580.2
PSA (Ų)
0.02
QED
3
Ro5 Violations
35
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H74N24O7
MW 955.15
Aromatic Rings 0
Heavy Atoms 67
NP-Likeness 0.17

Activity Summary

Ki 1 meas. best 6.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Furin
CHEMBL2611
Ki 6.94 6.94 114.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Furin Ki = 114.0 nM 6.94 Inhibition of furin 22682919

Literature References

PubMed DOI Target Context # Activities
22682919 10.1016/j.bmc.2012.05.029 Furin 1

Data from ChEMBL 36 via Core Engine