Compound Detail
CHEMBL2059680
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Basic Information
| ChEMBL ID | CHEMBL2059680 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJFZIEOLYPNJDJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
434.6
MW (Da)
5.31
ALogP
6
HBA
1
HBD
99.8
PSA (Ų)
0.49
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 CHEMBL4333 | EC50 | 6.8 | 6.8 | 158.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Fu | 0.0019 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 | EC50 | = | 158.49 | nM | 6.8 | Agonist activity against S1P1 receptor by cell based FRET assay | 22500954 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22500954 | 10.1021/jm2016107 | Sphingosine 1-phosphate receptor 1 | 1 |
| 22500954 | 10.1021/jm2016107 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine