Compound Detail
CHEMBL2070704
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Basic Information
| ChEMBL ID | CHEMBL2070704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NIOFUMBFHRRUHL-YDALLXLXSA-N |
| Parent Compound | CHEMBL2078868 |
| Active Moiety | CHEMBL2078868 |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
378.9
MW (Da)
3.04
ALogP
4
HBA
4
HBD
96.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.0
IC50 1 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | EC50 | 8.0 | 7.08 | 10.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of human recombinant CHK1 expressed in insect cells using biotinylami... | 22551018 |
| Serine/threonine-protein kinase Chk1 | EC50 | = | 10.0 | nM | 8.0 | Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin in... | 22551018 |
| Serine/threonine-protein kinase Chk1 | EC50 | = | 700.0 | nM | 6.16 | Inhibition of CHK1 in human HT29 cells assessed as check point abrogation | 22551018 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22551018 | 10.1021/jm300025r | Serine/threonine-protein kinase Chk1 | 3 |
Data from ChEMBL 36 via Core Engine