Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL2070881

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CN1CCC(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)CC1

Basic Information

ChEMBL ID CHEMBL2070881
Phase Preclinical
Structure Type MOL
InChI Key WOZSWFRDVYBRCX-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

395.4
MW (Da)
1.49
ALogP
9
HBA
2
HBD
118.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N9O2
MW 395.43
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness -1.91

Activity Summary

IC50 1 meas. best 6.04
Ki 1 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.6 6.6 253.0 1
Adenosine receptor A3
CHEMBL256
IC50 6.04 6.04 910.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22568637 10.1021/jm300323t Adenosine receptor A3 2
22568637 10.1021/jm300323t Adenosine receptor A1 1
22568637 10.1021/jm300323t Adenosine receptor A2a 1
22568637 10.1021/jm300323t Adenosine receptor A2b 1

Data from ChEMBL 36 via Core Engine