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Compound Detail

CHEMBL2071011

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O=C(Nc1nc(-c2ccc(OC(F)(F)F)cc2)cs1)[C@H]1CCCCN1S(=O)(=O)c1ccc(OC(F)(F)F)cc1

Basic Information

ChEMBL ID CHEMBL2071011
Phase Preclinical
Structure Type MOL
InChI Key DSPPDESMZKYNPV-LJQANCHMSA-N
0
Targets
0
Activities
0
Assay Types
2
PK Parameters
2
Publications
0
Known Names

Molecular Properties

595.5
MW (Da)
5.79
ALogP
7
HBA
1
HBD
97.8
PSA (Ų)
0.35
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H19F6N3O5S2
MW 595.54
Aromatic Rings 3
Heavy Atoms 39
NP-Likeness -1.80

Pharmacokinetic Data

Parameter Value Units Species
CL 7.9 mL.min-1.kg-1 Homo sapiens
CL 20.6 mL.min-1.kg-1 Rattus norvegicus

Literature References

PubMed DOI Target Context # Activities
22910039 10.1016/j.bmcl.2012.07.060 Liver microsomes 2
22910039 10.1016/j.bmcl.2012.07.060 Potassium voltage-gated channel subfamily KQT member 1 1

Data from ChEMBL 36 via Core Engine