Compound Detail
CHEMBL208411
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Basic Information
| ChEMBL ID | CHEMBL208411 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FBSYWZQEXIMEQD-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
471.6
MW (Da)
5.36
ALogP
3
HBA
2
HBD
77.8
PSA (Ų)
0.39
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.36
IC50 1 meas. best 7.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype CHEMBL4086 | IC50 | 7.33 | 7.33 | 47.0 | 1 |
| Prostaglandin E2 receptor EP4 subtype CHEMBL4086 | EC50 | 6.36 | 6.36 | 440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP4 subtype | IC50 | = | 47.0 | nM | 7.33 | Binding affinity to rat EP4 receptor expressed in HEK293 cells | 16442794 |
| Prostaglandin E2 receptor EP4 subtype | EC50 | = | 440.0 | nM | 6.36 | Activity at rat EP4 transfected in HEK293 cells by cAMP accumulation | 16442794 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16442794 | 10.1016/j.bmcl.2006.01.018 | Prostaglandin E2 receptor EP4 subtype | 3 |
| 16442794 | 10.1016/j.bmcl.2006.01.018 | Prostaglandin E2 receptor EP2 subtype | 1 |
Data from ChEMBL 36 via Core Engine