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Compound Detail

CHEMBL209332

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CCn1cc2c(n1)N=C(NC(=O)Nc1ccccc1OC)N1NC(c3ccco3)=NC21

Basic Information

ChEMBL ID CHEMBL209332
Phase Preclinical
Structure Type MOL
InChI Key MCYMDBGBWFAQTN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

420.4
MW (Da)
2.59
ALogP
9
HBA
3
HBD
121.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20N8O3
MW 420.43
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.41

Activity Summary

Ki 1 meas. best 9.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 9.25 9.25 0.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16821770 10.1021/jm051112+ Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine