Compound Detail
CHEMBL2096825
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Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2c(c1)n(C)c(=O)n2-c1cccc(Cl)c1
Basic Information
| ChEMBL ID | CHEMBL2096825 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VIPSZHALINMHRX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
479.4
MW (Da)
4.65
ALogP
6
HBA
1
HBD
65.0
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of bovine farnesyl transferase | 15911281 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15911281 | 10.1016/j.bmcl.2005.03.049 | Unchecked | 1 |
| 15911281 | 10.1016/j.bmcl.2005.03.049 | Geranylgeranyl transferase type I | 1 |
| 15911281 | 10.1016/j.bmcl.2005.03.049 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine