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Compound Detail

CHEMBL2103869

DASOLAMPANEL
🧪 Phase II
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🧪 Phase II
O=C(O)[C@@H]1C[C@H]2C[C@@H](Oc3cccc(Cl)c3-c3nnn[nH]3)CC[C@H]2CN1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2103869
Name DASOLAMPANEL
Phase Phase II
Structure Type MOL
InChI Key LAKQPSQCICNZII-NOHGZBONSA-N

Known Names

Dasolampanel NGX426
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
2
Known Names
2
Mechanisms

Molecular Properties

377.8
MW (Da)
2.13
ALogP
6
HBA
3
HBD
113.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -ampa-
USAN Year 2011

Extended Properties

Molecular Formula C17H20ClN5O3
MW 377.83
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.06

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Glutamate receptor ionotropic AMPA antagonist ANTAGONIST Glutamate receptor ionotropic AMPA ✓ ✓
Glutamate receptor ionotropic kainate 1 antagonist ANTAGONIST Glutamate receptor ionotropic, kainate 1 ✓ ✓

Data from ChEMBL 36 via Core Engine