Compound Detail
CHEMBL2103880
CERLAPIRDINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2103880 |
| Name | CERLAPIRDINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NXQGEDVQXVTCDA-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
7
Known Names
1
Indications
1
Mechanisms
Molecular Properties
409.5
MW (Da)
3.88
ALogP
5
HBA
1
HBD
75.3
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serotonin 6 (5-HT6) receptor antagonist | ANTAGONIST | 5-hydroxytryptamine receptor 6 | ✓ | ✓ |
Indications
Alzheimer Disease
Activity Summary
Ki 3 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 8.89 | 8.89 | 1.3 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 1.3 | nM | 8.89 | Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells | 24850589 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 1.3 | nM | 8.89 | Antagonist activity at 5-HT6 receptor (unknown origin) | 28212021 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 1.3 | nM | 8.89 | Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant | 34311086 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24850589 | 10.1021/jm5003952 | 5-hydroxytryptamine receptor 6 | 1 |
| 28212021 | 10.1021/acs.jmedchem.6b01662 | Rattus norvegicus | 1 |
| 28212021 | 10.1021/acs.jmedchem.6b01662 | 5-hydroxytryptamine receptor 6 | 1 |
| 34311086 | 10.1016/j.bmcl.2021.128275 | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine