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Compound Detail

CHEMBL2104161

CLOPIMOZIDE
🧪 Phase II
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🧪 Phase II
O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2104161
Name CLOPIMOZIDE
Phase Phase II
Structure Type MOL
InChI Key JCZYXTVBWHAWLL-UHFFFAOYSA-N

Known Names

Clopimozida Clopimozide NSC-335305 R 29,764 R-29764
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
5
Known Names

Molecular Properties

496.0
MW (Da)
6.51
ALogP
3
HBA
1
HBD
41.0
PSA (Ų)
0.32
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Year 1975

Extended Properties

Molecular Formula C28H28ClF2N3O
MW 496.00
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -1.19

Activity Summary

IC50 1 meas. best 5.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toxoplasma gondii
CHEMBL612888
 IC50 5.75 5.75 1800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Toxoplasma gondii IC50 = 1800.0 nM 5.75 Antiparasitic activity against Toxoplasma gondii 31585276

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
31585276 10.1016/j.ejmech.2019.111711 Toxoplasma gondii 1
31708262 10.1016/j.bmcl.2019.126754 Cholinesterase 1

Data from ChEMBL 36 via Core Engine