Compound Detail

CHEMBL2105648

PALOVAROTENE

💊 Approved Drug

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💊 Approved Drug

CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2105648
Name	PALOVAROTENE
Phase	Approved
Structure Type	MOL
InChI Key	YTFHCXIPDIHOIA-DHZHZOJOSA-N
Therapeutic	✓ Yes

Known Names

CLM-001 IPN-60120 IPN60120 Palovarotene Palovaroteno R-667 RG-667 RO-3300074 RO3300074 Sohonos

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

414.6

MW (Da)

6.15

ALogP

HBA

HBD

55.1

PSA (Å²)

0.51

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	2023
Availability	Prescription
Chirality	Achiral

Routes of Administration

Oral

Flags

Black Box Warning Natural Product First in Class

USAN Stem	-arotene
USAN Year	2008

Extended Properties

Molecular Formula	C27H30N2O2
MW	414.55
Aromatic Rings	3
Heavy Atoms	31
NP-Likeness	-0.39

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Retinoic acid receptor gamma agonist	AGONIST	Retinoic acid receptor gamma	✓	✓

Indications

Myositis Ossificans Dry Eye Syndromes Ossification, Heterotopic

ATC Classification

M09AX11

palovarotene

Level 1: MUSCULO-SKELETAL SYSTEM

Level 2: OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM

Drug Warnings

Black Box Warning

General Warning

Country: United States

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
-	10.21203/rs.3.rs-23951/v1	SARS-CoV-2	1
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	1

Data from ChEMBL 36 via Core Engine