Compound Detail
CHEMBL2106650
MOSAPRAMINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2106650 |
| Name | MOSAPRAMINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PXUIZULXJVRBPC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
3
Known Names
1
Indications
Molecular Properties
479.1
MW (Da)
4.74
ALogP
4
HBA
1
HBD
38.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Psychotic Disorders
ATC Classification
N05AX10
mosapramine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS
Activity Summary
Ki 1 meas. best 10.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 10.52 | 10.52 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 0.03 | nM | 10.52 | Agonist activity at dopamine D4 receptor (unknown origin) | 31404862 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4651402 | Vero C1008 | 2 |
| 31404862 | 10.1016/j.ejmech.2019.111569 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine