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Compound Detail

CHEMBL2107726

ARIMOCLOMOL
💊 Approved Drug
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💊 Approved Drug
[O-][n+]1cccc(/C(Cl)=N/OC[C@H](O)CN2CCCCC2)c1

Basic Information

ChEMBL ID CHEMBL2107726
Name ARIMOCLOMOL
Phase Approved
Structure Type MOL
InChI Key SGEIEGAXKLMUIZ-XUVDNFPMSA-N
Therapeutic ✓ Yes

Known Names

Arimoclomol BRX-220 FREE BASE
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
2
Publications
2
Known Names
4
Indications

Molecular Properties

313.8
MW (Da)
1.08
ALogP
5
HBA
1
HBD
72.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2024
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product First in Class
USAN Stem -clomol
USAN Year 2018

Extended Properties

Molecular Formula C14H20ClN3O3
MW 313.79
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -1.10

Indications

Amyotrophic Lateral Sclerosis Myositis, Inclusion Body Gaucher Disease Niemann-Pick Disease, Type C

ATC Classification

N07XX17
arimoclomol
Level 1: NERVOUS SYSTEM
Level 2: OTHER NERVOUS SYSTEM DRUGS

Literature References

PubMed DOI Target Context # Activities
23458846 10.1021/jm3015926 Mus musculus 1
27372371 10.1016/j.ejmech.2016.06.017 Superoxide dismutase [Cu-Zn] 1

Data from ChEMBL 36 via Core Engine