Compound Detail
CHEMBL211052
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCN1C(=O)[C@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)N=C(c2ccccc2)c2ccccc21
Basic Information
| ChEMBL ID | CHEMBL211052 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SSWCBXZFRVUVJD-NDEPHWFRSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
536.6
MW (Da)
4.44
ALogP
4
HBA
2
HBD
97.3
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Ki 1 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 CHEMBL2107838 | Ki | 6.05 | 6.05 | 897.0 | 1 |
| Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 CHEMBL2107838 | IC50 | 6.0 | 6.0 | 990.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | Ki | = | 897.0 | nM | 6.05 | Displacement of [125I]CGRP from human cloned CLR/RAMP1 receptor expressed in E10... | 16527483 |
| Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | IC50 | = | 990.0 | nM | 6.0 | Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells me... | 16527483 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16527483 | 10.1016/j.bmcl.2006.02.051 | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | 2 |
Data from ChEMBL 36 via Core Engine