Compound Detail
CHEMBL213090
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Basic Information
| ChEMBL ID | CHEMBL213090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QLTKHQBBVFTAHY-NDEPHWFRSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
518.8
MW (Da)
4.96
ALogP
5
HBA
5
HBD
116.5
PSA (Ų)
0.12
QED
1
Ro5 Violations
24
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 1 CHEMBL3753 | Ki | 7.11 | 6.3133 | 77.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 1 | Ki | = | 77.0 | nM | 7.11 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
| Glutamate receptor 1 | Ki | = | 480.0 | nM | 6.32 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
| Glutamate receptor 1 | Ki | = | 3100.0 | nM | 5.51 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16942015 | 10.1021/jm060606j | Glutamate receptor 1 | 3 |
| 16942015 | 10.1021/jm060606j | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine