Compound Detail
CHEMBL214038
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Basic Information
| ChEMBL ID | CHEMBL214038 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XCAYLCMRVNKMHD-SFHVURJKSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.5
MW (Da)
1.05
ALogP
5
HBA
5
HBD
116.5
PSA (Ų)
0.31
QED
0
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.85
IC50 1 meas. best 4.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 1 CHEMBL3753 | Ki | 6.85 | 6.3533 | 140.0 | 3 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.91 | 4.91 | 12330.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 1 | Ki | = | 140.0 | nM | 6.85 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
| Glutamate receptor 1 | Ki | = | 410.0 | nM | 6.39 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
| Glutamate receptor 1 | Ki | = | 1500.0 | nM | 5.82 | Antagonist activity against rat GluR1 flop expressed in Xenopus laevis oocyte as... | 16942015 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 12330.0 | nM | 4.91 | Antagonist activity against rat brain AMPA receptor expressed in Xenopus laevis ... | 16942015 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16942015 | 10.1021/jm060606j | Glutamate receptor 1 | 3 |
| 16942015 | 10.1021/jm060606j | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine