Compound Detail
CHEMBL214599
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Basic Information
| ChEMBL ID | CHEMBL214599 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZYOGWGIQJFWQU-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
348.4
MW (Da)
4.63
ALogP
3
HBA
1
HBD
66.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 4 CHEMBL3190 | EC50 | 6.62 | 6.075 | 242.0 | 2 |
| Glutamate receptor 2 CHEMBL4016 | EC50 | 6.46 | 6.225 | 345.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 4 | EC50 | = | 242.0 | nM | 6.62 | Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as ... | 16872827 |
| Glutamate receptor 2 | EC50 | = | 345.0 | nM | 6.46 | Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as ... | 16872827 |
| Glutamate receptor 2 | EC50 | = | 1035.0 | nM | 5.99 | Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as ... | 16872827 |
| Glutamate receptor 4 | EC50 | = | 2947.0 | nM | 5.53 | Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as ... | 16872827 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16872827 | 10.1016/j.bmcl.2006.07.012 | Glutamate receptor 4 | 2 |
| 16872827 | 10.1016/j.bmcl.2006.07.012 | Glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine