Compound Detail
CHEMBL2146832
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2146832 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JCSMWROUIBBVBP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
414.5
MW (Da)
4.21
ALogP
5
HBA
0
HBD
60.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.4 | 5.4 | 4010.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 4010.0 | nM | 5.4 | Inhibition of full length GST-tagged mouse B-Raf V600E mutant-mediated MEK1 phos... | 22985962 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22985962 | 10.1016/j.bmc.2012.08.043 | Unchecked | 1 |
| 22985962 | 10.1016/j.bmc.2012.08.043 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine