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Compound Detail

CHEMBL2153759

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COc1ccc(S(=O)(=O)/N=C(\NCC(N)=O)N2CC(c3ccccc3)C(c3ccc(Cl)cc3)=N2)cc1

Basic Information

ChEMBL ID CHEMBL2153759
Phase Preclinical
Structure Type MOL
InChI Key YOJCUELXDGGLDN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

526.0
MW (Da)
2.97
ALogP
5
HBA
2
HBD
126.5
PSA (Ų)
0.36
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H24ClN5O4S
MW 526.02
Aromatic Rings 3
Heavy Atoms 36
NP-Likeness -1.02

Activity Summary

IC50 1 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL218
IC50 7.0 7.0 100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cannabinoid receptor 1 IC50 = 100.0 nM 7.0 Displacement of 3[H]ligand from recombinant human CB1 receptor 22959249

Literature References

PubMed DOI Target Context # Activities
22959249 10.1016/j.bmcl.2012.08.004 Cannabinoid receptor 1 1
22959249 10.1016/j.bmcl.2012.08.004 Cannabinoid receptor 2 1

Data from ChEMBL 36 via Core Engine