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Compound Detail

CHEMBL2163533

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C=CCN1CC[C@]23c4c5ccc(OC)c4O[C@H]2[C@H](NC(=O)c2cccc(I)c2)CC[C@@]3(O)[C@H]1C5

Basic Information

ChEMBL ID CHEMBL2163533
Phase Preclinical
Structure Type MOL
InChI Key ZLHDSOVTSCMPOY-XGTKUTNFSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

572.4
MW (Da)
3.44
ALogP
5
HBA
2
HBD
71.0
PSA (Ų)
0.42
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H29IN2O4
MW 572.44
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness 0.53

Literature References

PubMed DOI Target Context # Activities
22734622 10.1021/jm300305c Mu-type opioid receptor 1
22734622 10.1021/jm300305c Kappa-type opioid receptor 1
22734622 10.1021/jm300305c Delta-type opioid receptor 1
22734622 10.1021/jm300305c Unchecked 1
22734622 10.1021/jm300305c Mus musculus 1

Data from ChEMBL 36 via Core Engine