Compound Detail
CHEMBL2164372
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Basic Information
| ChEMBL ID | CHEMBL2164372 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ADTJNFNFTUUFIJ-UCFFOFKASA-N |
2
Targets
3
Activities
1
Assay Types
2
PK Parameters
6
Publications
0
Known Names
Molecular Properties
434.4
MW (Da)
3.58
ALogP
4
HBA
1
HBD
67.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 6.28 | 5.44 | 520.0 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 4.77 | 4.77 | 17000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 50.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 28.0 | mL.min-1.g-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 520.0 | nM | 6.28 | Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells a... | 22770500 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 17000.0 | nM | 4.77 | Binding affinity to human ERG expressed in CHOK1 cells by IonWorks HT assay | 22770500 |
| Sodium channel protein type 9 subunit alpha | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells a... | 22770500 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22770500 | 10.1021/jm300623u | Liver microsomes | 2 |
| 22770500 | 10.1021/jm300623u | Sodium channel protein type 9 subunit alpha | 2 |
| - | 10.6019/CHEMBL3301361 | ADMET | 2 |
| 22770500 | 10.1021/jm300623u | No relevant target | 1 |
| 22770500 | 10.1021/jm300623u | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 22770500 | 10.1021/jm300623u | Sodium channel protein type 5 subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine