Compound Detail
CHEMBL2164457
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Basic Information
| ChEMBL ID | CHEMBL2164457 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RUZIZPNQGMERCW-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
474.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Carboxypeptidase B CHEMBL4065 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Carboxypeptidase B2 CHEMBL3419 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.07 | 8.07 | 8.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Carboxypeptidase B | IC50 | = | 1.1 | nM | 8.96 | Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incub... | 22891675 |
| Carboxypeptidase B2 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 m... | 22891675 |
| Unchecked | IC50 | = | 8.6 | nM | 8.07 | Inhibition of human carboxypeptidase N using Hip-Lys as substrate incubated for ... | 22891675 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22891675 | 10.1021/jm300735t | Carboxypeptidase B2 | 3 |
| 22891675 | 10.1021/jm300735t | Unchecked | 2 |
| 22891675 | 10.1021/jm300735t | Carboxypeptidase B | 2 |
Data from ChEMBL 36 via Core Engine