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Compound Detail

CHEMBL2165124

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CCOc1ccc(N2CCN(CCCCOc3ccc4c(c3)NC(=O)CC4)CC2)cc1

Basic Information

ChEMBL ID CHEMBL2165124
Phase Preclinical
Structure Type MOL
InChI Key QMMMRXVBSGZXCO-UHFFFAOYSA-N
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

423.6
MW (Da)
3.95
ALogP
5
HBA
1
HBD
54.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H33N3O3
MW 423.56
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -1.09

Activity Summary

EC50 2 meas. best 7.3
Ki 1 meas. best 7.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
EC50 7.3 6.95 50.0 2
D(2) dopamine receptor
CHEMBL217
Ki 7.28 7.28 53.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22845053 10.1021/jm300603y D(2) dopamine receptor 5

Data from ChEMBL 36 via Core Engine