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Compound Detail

CHEMBL2179620

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O=C([O-])c1cc(-c2cccc(-c3ccc4c(c3)CN(C3CCCC3)C4=O)c2)ccc1Cl.[Na+]

Basic Information

ChEMBL ID CHEMBL2179620
Phase Preclinical
Structure Type MOL
InChI Key VWXYMXTXEIPDCD-UHFFFAOYSA-M
Parent Compound CHEMBL2179646
Active Moiety CHEMBL2179646
0
Targets
0
Activities
0
Assay Types
11
PK Parameters
5
Publications
0
Known Names

Molecular Properties

431.9
MW (Da)
6.27
ALogP
2
HBA
1
HBD
57.6
PSA (Ų)
0.53
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H21ClNNaO3
MW 453.90
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.51

Pharmacokinetic Data

Parameter Value Units Species
AUC 1393663.31 ng.hr.mL-1 Rattus norvegicus
AUC 1151.93 ng.hr.mL-1 Rattus norvegicus
CL - - Rattus norvegicus
Cmax 2000.0 nM Rattus norvegicus
Cmax 400.0 nM Rattus norvegicus
F - % Rattus norvegicus
T1/2 2.01 hr Rattus norvegicus
T1/2 3.06 hr Rattus norvegicus
Tmax 0.5 hr Rattus norvegicus
Vd 21.2 ml Rattus norvegicus
Vd 96.2 ml Rattus norvegicus

Literature References

PubMed DOI Target Context # Activities
23009245 10.1021/jm3005306 Rattus norvegicus 11
23009245 10.1021/jm3005306 Nucleic Acid 1
23009245 10.1021/jm3005306 Plasma 1
23009245 10.1021/jm3005306 Brain 1
23009245 10.1021/jm3005306 Metabotropic glutamate receptor 2 1

Data from ChEMBL 36 via Core Engine