Compound Detail

CHEMBL2204283

MSD-M1PAM-NC

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N#CC1(c2ccccn2)CCN(Cc2cc(C(=O)N3CCCC3)c(=O)n3ccccc23)CC1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2204283
Name	MSD-M1PAM-NC
Phase	Preclinical
Structure Type	MOL
InChI Key	ASAKPTPDFNXOQN-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

441.5

MW (Da)

2.99

ALogP

HBA

HBD

81.7

PSA (Å²)

0.62

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL4507295	Tyrosine-protein kinase ABL1	15
-	10.6019/CHEMBL5674860	Colon cancer organoid	12
-	10.6019/CHEMBL5724558	Colon cancer organoid	12
-	10.6019/CHEMBL4507295	Epidermal growth factor receptor	12
-	10.6019/CHEMBL4507295	Receptor-type tyrosine-protein kinase FLT3	11
-	10.6019/CHEMBL4689842	HEK-293T	10
-	10.6019/CHEMBL4507295	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	10
-	10.6019/CHEMBL4507295	Mast/stem cell growth factor receptor Kit	9
-	10.6019/CHEMBL4689842	Fibroblast	8
-	10.6019/CHEMBL4507295	Unchecked	8
-	10.6019/CHEMBL5608141	Colon cancer organoid	6
-	10.6019/CHEMBL4689842	U2OS	5
-	10.1158/2159-8290.CD-23-0050	Colon cancer organoid	5
-	10.6019/CHEMBL4507295	Proto-oncogene tyrosine-protein kinase receptor Ret	4
-	10.6019/CHEMBL4507295	ALK tyrosine kinase receptor	3
-	10.6019/CHEMBL4507295	Hepatocyte growth factor receptor	3
-	10.6019/CHEMBL4507295	Tyrosine-protein kinase JAK1	2
-	10.6019/CHEMBL4507295	Macrophage colony-stimulating factor 1 receptor	2
-	10.6019/CHEMBL4507295	Ribosomal protein S6 kinase alpha-5	2
-	10.6019/CHEMBL4507295	Ribosomal protein S6 kinase alpha-4	2

Data from ChEMBL 36 via Core Engine