Compound Detail
CHEMBL2205734
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Basic Information
| ChEMBL ID | CHEMBL2205734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZABGYSAZFSNLAY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
412.9
MW (Da)
6.41
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha CHEMBL4261 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha | IC50 | = | 3.0 | nM | 8.52 | Inhibition of HIF-1alpha in human HCT116 cells under hypoxia condition by HRE-lu... | 22305612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22305612 | 10.1016/j.ejmech.2012.01.033 | Hypoxia-inducible factor 1-alpha | 1 |
Data from ChEMBL 36 via Core Engine