Compound Detail
CHEMBL2206437
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Basic Information
| ChEMBL ID | CHEMBL2206437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEYCZBOQOUBOIW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
402.9
MW (Da)
5.00
ALogP
4
HBA
0
HBD
33.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 7.21 | 7.21 | 61.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 61.66 | nM | 7.21 | Agonist activity at human mGLuR2 expressed in CHO cell membrane assessed as [32S... | 22992024 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22992024 | 10.1021/jm300912k | Metabotropic glutamate receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine