Compound Detail
CHEMBL222275
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Basic Information
| ChEMBL ID | CHEMBL222275 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUIRQMAMPLLXCL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
430.6
MW (Da)
4.43
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.63
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 5.85 | 5.85 | 1400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 1400.0 | nM | 5.85 | Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 c... | 15588097 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15588097 | 10.1021/jm049702f | 5-hydroxytryptamine receptor 7 | 1 |
| 15588097 | 10.1021/jm049702f | 5-hydroxytryptamine receptor 1A | 1 |
| 15588097 | 10.1021/jm049702f | 5-hydroxytryptamine receptor 2A | 1 |
Data from ChEMBL 36 via Core Engine