Compound Detail
CHEMBL22274
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Basic Information
| ChEMBL ID | CHEMBL22274 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FBHYBXRWVNVMRY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
223.6
MW (Da)
2.29
ALogP
3
HBA
2
HBD
70.4
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.39 | 4.39 | 41000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 41000.0 | nM | 4.39 | Inhibition of [3H]-AMPA binding to AMPA receptor of rat cortical membrane | 1826744 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1826744 | 10.1021/jm00108a002 | Glutamate NMDA receptor | 3 |
| 1826744 | 10.1021/jm00108a002 | Glutamate receptor ionotropic, AMPA | 2 |
| 1826744 | 10.1021/jm00108a002 | Glutamate receptor ionotropic, kainate | 2 |
Data from ChEMBL 36 via Core Engine