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Compound Detail

CHEMBL2228003

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CCOCCOC(=O)/C(C#N)=C(\NCc1cnc(Cl)s1)C(C)C

Basic Information

ChEMBL ID CHEMBL2228003
Phase Preclinical
Structure Type MOL
InChI Key KARPCFDOBUYODZ-SEYXRHQNSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

357.9
MW (Da)
2.90
ALogP
7
HBA
1
HBD
84.2
PSA (Ų)
0.32
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H20ClN3O3S
MW 357.86
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -1.38

Activity Summary

IC50 1 meas. best 6.79

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Spinacia oleracea
CHEMBL612824
IC50 6.79 6.79 162.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Spinacia oleracea IC50 = 162.18 nM 6.79 Inhibition of photosynthetic electron transport in Spinacia oleracea (spinach)is... 18052098

Literature References

PubMed DOI Target Context # Activities
15053529 10.1021/jf035312a Brassica napus 10
18052098 10.1021/jf072851x Brassica napus 6
15053529 10.1021/jf035312a Amaranthus retroflexus 5
18052098 10.1021/jf072851x Amaranthus retroflexus 4
18052098 10.1021/jf072851x Spinacia oleracea 2
18052098 10.1021/jf072851x Digitaria sanguinalis 2
18052098 10.1021/jf072851x Medicago sativa 2
15053529 10.1021/jf035312a Medicago sativa 2

Data from ChEMBL 36 via Core Engine