Compound Detail
CHEMBL224496
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN1CCN(Cc2ccc3c(c2)-c2[nH]nc(-c4csc(C#CCOc5ccccc5)c4)c2C3)CC1
Basic Information
| ChEMBL ID | CHEMBL224496 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZPBJXPCUQTFPS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
4.89
ALogP
5
HBA
1
HBD
44.4
PSA (Ų)
0.36
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.38 | 7.045 | 42.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 42.0 | nM | 7.38 | Inhibition of human KDR kinase by HTRF assay | 17425296 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 197.0 | nM | 6.71 | Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T... | 17425296 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17425296 | 10.1021/jm061223o | Vascular endothelial growth factor receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine