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Compound Detail

CHEMBL225221

KENGANTHRANOL C
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COC1c2c(CC=C(C)C)c(C)cc(O)c2C(=O)c2c(O)cc3c(c21)CC(C(C)(C)O)O3

Basic Information

ChEMBL ID CHEMBL225221
Name KENGANTHRANOL C
Phase Preclinical
Structure Type MOL
InChI Key XIQDGAKRANNCDI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

438.5
MW (Da)
4.27
ALogP
6
HBA
3
HBD
96.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H30O6
MW 438.52
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness 2.41

Activity Summary

IC50 1 meas. best 4.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.66 4.66 21900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 21900.0 nM 4.66 Inhibition of Saccharomyces sp. alpha glucosidase by spectrophotometry 16499321

Literature References

PubMed DOI Target Context # Activities
17352491 10.1021/np060556l Priestia megaterium 2
17352491 10.1021/np060556l [Chlorella] fusca 2
17352491 10.1021/np060556l Microbotryum violaceum 2
16499321 10.1021/np050407n Unchecked 2

Data from ChEMBL 36 via Core Engine