Compound Detail
CHEMBL2261921
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)(C)OC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1cc(C#C[Si](C)(C)C)ccc1-2
Basic Information
| ChEMBL ID | CHEMBL2261921 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCBAIIQUIRAZRU-IBGZPJMESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
435.6
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 CHEMBL2094122 | Ki | 6.99 | 6.99 | 103.0 | 1 |
| GABA A receptor alpha-4/beta-3/gamma-2 CHEMBL2111366 | Ki | 6.76 | 6.76 | 175.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 | Ki | = | 103.0 | nM | 6.99 | Displacement of [3H]-Ro 15-1788 from Homo sapiens (human) recombinant GABAA alph... | - |
| GABA A receptor alpha-4/beta-3/gamma-2 | Ki | = | 175.0 | nM | 6.76 | Displacement of [3H]-Ro 15-4513 from Homo sapiens (human) recombinant GABAA alph... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-004-0033-7 | GABA-A receptor; alpha-6/beta-3/gamma-2 | 1 |
| - | 10.1007/s00044-004-0033-7 | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
| - | 10.1007/s00044-004-0033-7 | GABA A receptor alpha-4/beta-3/gamma-2 | 1 |
| - | 10.1007/s00044-004-0033-7 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
| - | 10.1007/s00044-004-0033-7 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| - | 10.1007/s00044-004-0033-7 | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine