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Compound Detail

CHEMBL2270715

8-Cl-D-DIBOA
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O=C1COc2c(Cl)cccc2N1O

Basic Information

ChEMBL ID CHEMBL2270715
Name 8-Cl-D-DIBOA
Phase Preclinical
Structure Type MOL
InChI Key WSYPKJIPQMYNKZ-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

199.6
MW (Da)
1.45
ALogP
3
HBA
1
HBD
49.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H6ClNO3
MW 199.59
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness -0.51

Activity Summary

IC50 2 meas. best 4.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Echinochloa crus-galli
CHEMBL612343
IC50 4.36 4.36 44000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Echinochloa crus-galli IC50 = 44000.0 nM 4.36 Herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as ... 19551813

Literature References

PubMed DOI Target Context # Activities
19551813 10.1002/ps.1799 Oryza sativa 2
19551813 10.1002/ps.1799 Echinochloa crus-galli 2
19551813 10.1002/ps.1799 Unchecked 1

Data from ChEMBL 36 via Core Engine