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Compound Detail

CHEMBL2271013

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COc1cccc(NC(=O)N(C)C)c1

Basic Information

ChEMBL ID CHEMBL2271013
Phase Preclinical
Structure Type MOL
InChI Key BGDUKFUILQWOAE-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

194.2
MW (Da)
1.79
ALogP
2
HBA
1
HBD
41.6
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H14N2O2
MW 194.23
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -1.74

Activity Summary

IC50 2 meas. best 5.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Photosystem II protein D1
CHEMBL2366481
IC50 5.2 5.2 6309.6 1
Photosystem II protein D1
CHEMBL2366463
IC50 4.3 4.3 50118.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1271/bbb.57.1389 Photosystem II protein D1 2
- 10.1271/bbb.57.1389 No relevant target 1
- 10.1271/bbb.57.1389 Vigna radiata var. radiata 1

Data from ChEMBL 36 via Core Engine