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Compound Detail

CHEMBL2271051

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O=C1C(C(O)c2ccc3c(c2)OCCO3)CCCN1Cc1ccccc1

Basic Information

ChEMBL ID CHEMBL2271051
Phase Preclinical
Structure Type MOL
InChI Key HOCKLGZDTABYEP-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

353.4
MW (Da)
2.93
ALogP
4
HBA
1
HBD
59.0
PSA (Ų)
0.92
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H23NO4
MW 353.42
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.30

Activity Summary

IC50 2 meas. best 8.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Echinochloa esculenta
CHEMBL2367301
IC50 8.06 8.06 8.8 1
Oryza sativa
CHEMBL613061
IC50 8.0 8.0 10.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1584/jpestics.26.143 Echinochloa esculenta 5
- 10.1584/jpestics.26.143 Oryza sativa 2

Data from ChEMBL 36 via Core Engine