Compound Detail
CHEMBL22749
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COc1ccc(CN(CCN(C)CCCCCCNS(=O)(=O)c2cccc3c(N(C)C)cccc23)c2ccccn2)cc1
Basic Information
| ChEMBL ID | CHEMBL22749 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOCSMPABENXVNX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
603.8
MW (Da)
5.79
ALogP
7
HBA
1
HBD
78.0
PSA (Ų)
0.15
QED
2
Ro5 Violations
17
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | Kd | 7.75 | 7.75 | 17.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | Kd | = | 17.78 | nM | 7.75 | Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescen... | 12657255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12657255 | 10.1016/s0960-894x(03)00113-6 | Histamine H1 receptor | 2 |
Data from ChEMBL 36 via Core Engine