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Compound Detail

CHEMBL229299

CARBOXYNAPHTHOL
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O=C(O)c1ccc2ccccc2c1O

Basic Information

ChEMBL ID CHEMBL229299
Name CARBOXYNAPHTHOL
Phase Preclinical
Structure Type MOL
InChI Key SJJCQDRGABAVBB-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

188.2
MW (Da)
2.24
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C11H8O3
MW 188.18
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness 0.15

Activity Summary

IC50 1 meas.
Kd 1 meas. best 3.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
L-lactate dehydrogenase A chain
CHEMBL4835
Kd 3.19 3.19 640000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22417091 10.1021/jm201734r L-lactate dehydrogenase A chain 3
21778065 10.1016/j.bmc.2011.06.080 No relevant target 2
8831754 10.1021/jm960229i Monoclonal antibody (mAb) 1
17692525 10.1016/j.bmc.2007.07.010 Tyrosine-protein phosphatase non-receptor type 1 1
21778065 10.1016/j.bmc.2011.06.080 Neuraminidase 1
21778065 10.1016/j.bmc.2011.06.080 Influenza A virus 1
22417091 10.1021/jm201734r L-lactate dehydrogenase B chain 1
22963087 10.1021/jm3009844 MDCK 1
22963087 10.1021/jm3009844 Influenza A virus 1
22963087 10.1021/jm3009844 Neuraminidase 1

Data from ChEMBL 36 via Core Engine